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Wellbutrin (bupropion) is an antidepressant medication. It works in the brain to treat depression.

Wellbutrin generic 75 mg; 1 x tablet twice daily), paroxetine (25 mg; 1 x tablet twice daily) and sertraline (20 mg; 1 wellbutrin generic 150 mg x tablet twice daily). In a total of 12 weeks, the mean proportion of days with at least 2 antidepressant doses did not differ significantly between the active- and placebo-controlled groups (16.3% with active vs 18.7% placebo for days 1 to 7, P=0.45; 17.9% with active vs 19.7% placebo for days 8 to 14, P=0.44; 17.8% with active vs 18.1% placebo for days 15 to 21, P=0.52). Conclusions and Relevance In this trial, the mean proportion of days at least 2 antidepressant doses did not differ significantly between the 2 active- and placebo-controlled groups. The results suggest that there is no evidence of an effect antidepressant medication on the proportion of days with at least 2 antidepressant doses. Trial Registration clinicaltrials.gov Identifier: NCT01710597 Introduction A large proportion of patients with treatment-resistant depression are treated antidepressants.1,2 While some authors3-7 have found positive results for this form of treatment, many patients experience adverse events, including impotence, dizziness, and somnolence.8,9 The adverse reactions to antidepressants may reflect either pharmacotherapy or antidepressant-evoked physiologic processes.10-13 Most patients will have at least 1 adverse reaction to their antidepressants.1,6 However, most of this response is short-term.7,16 The antidepressant medication literature presents a number of small scale, noninstitutionalized, randomized, double-blind placebo-controlled studies.17-22 However, few of these studies have included an active comparison to placebo and compared antidepressants within Wellbutrin online sales a single intervention. This may be because some studies22-26 used a very high dosage of single antidepressant drug,26,27 or because the data were restricted to a period less than 1 week. However, the results of most these studies were inconsistent and of limited quality.6,22,27-32 Therefore, the purpose of this study was to compare the number of antidepressant doses that were required in the first week of treatment with and without placebo in a clinical trial of 8 weeks duration, with a relatively high number of antidepressant- and placebo-controlled treatments. Methods Study design and randomization This was an active follow-up, double-blind, placebo-controlled trial on patients with severe unipolar depression, and was conducted at 2 institutions in the Netherlands. Two groups were studied: a standard of care control group (treatment as usual; treatment usual group) and an experimental group with different antidepressant doses (40 mg, 75 and 100 mg). The experimental group was divided into 2 treatment arms. Both treatments were assigned to a similar number of patients (n=18) in the treatment as usual group (N: 19), and the treatments were separated by 28 days so that no best drugstore eye cream hydrating patient was randomly allocated to more than 1 treatment. The primary outcome measure was number of days for which at least 2 active antidepressant or placebo treatment doses were required. The dose of each antidepressant/placebo was chosen to match the dose most frequently prescribed in the study population to determine dose-response. Patients received their treatments for a 28-day treatment period. The treatment period for experimental groups Wellbutrin 300mg $234.93 - $1.96 Per pill was shorter.

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